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Gender-Specific Outcomes After Sirolimus-Eluting Stent Implantation
Topic: Interventional Cardiology
Study Question: What is the outcome of women undergoing implantation of sirolimus-eluting stents (SES)?
Methods: The authors pooled data from four trials (RAVEL, SIRIUS, E-SIRIUS, and C-SIRIUS) that randomized patients undergoing percutaneous coronary intervention to SES versus bare-metal stents (BMS) and analyzed the impact of gender on outcome.
Results: Of the total 1,748 patients, 497 were women and were equally randomized to SES (n = 249) versus BMS (n = 248). Women were older than men and more likely to have diabetes, hypertension, and congestive heart failure. Use of SES in women was associated with a marked reduction in binary restenosis (SES 6.3% vs. 43.8%), target lesion revascularization (4.1% vs. 18.3%), or target vessel revascularization (TVR, 6.9 % vs. 20.4%). There was no impact of gender on the anti-restenotic efficacy of SES.
Conclusions: Compared with men, females have a similar reduction in restenosis with SES.
Perspective:
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